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The comparison between the efficacy of high dose acyclovir and erythromycin on the period and signs of pitiriasis rosea

Indian Journal of Dermatology, 09/30/2010  Free full text Clinical Article

Ehsani A et al. – A total of 30 patients including 15 males and 15 females completed the study. After eight weeks, 13 patients in the acyclovir group experienced complete response, while in the erythromycin group only six patients had complete response. Also, patients in the acyclovir group experienced faster resolution of pruritus in comparison with the erythromycin group (not significant). No adverse drug reaction was detected in both groups. It seemed that a high–dose of oral acyclovir was a safe and effective therapy for pitiriasis rosea, although this remained to be confirmed in larger studies.