I have long had the idea that God created psoriasis and warts to teach dermatologists the merits of humility.
(Vincent Joseph Derbes, 1981)
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Monday, August 17, 2009
Comparative efficacy of thalidomide and prednisolone in the treatment of moderate to severe erythema nodosum leprosum: a randomized study
Kaur I, Dogra S, Narang T, De D; Australasian Journal of Dermatology 50 (3), 181-5 (Aug 2009)
The present study was undertaken to compare the efficacy and safety of thalidomide to that of oral prednisolone in the treatment of moderate to severe type 2 lepra reaction. Sixty patients with a histologically confirmed diagnosis of erythema nodosum leprosum with a clinical score of 4 or more (i.e. moderate to severe type 2 reaction) were randomly allocated to two groups comprising 30 patients each. Group 1 patients were given thalidomide at a dose of 300 mg/day for 1 week and the dose was gradually reduced, and Group 2 received prednisolone 40 mg daily for 2 weeks, which was tapered by 10 mg every 2 weeks. Thalidomide induced a faster clinical response (cutaneous as well as systemic) compared with prednisolone. Patients taking thalidomide had fewer relapses and a longer period of remission than those receiving prednisolone.
*.General Surgeon (Hue,VN); *. ENT (Hue,VN); *. Leprosy Surgeon (I.L.A.D); *.Leprologist (C.E.S de Léprologie, Dakar, Senegal); *.Level II Dermatologist (HCMC);
*.Speaker at The Combined Congress of 27th Asean Orthopedic Association-6th Vietnamese Orthopedic Association-12th Spine society of HCM city (HCMC-December, 2007); *.International Hospital Federation 1996 Associate Fellow (Hongkong-London);
*.Fellowship in Saint- Louis Hospital at Department of Plastic Surgery and Department of Dermatology (Paris, 2008).
*.Fellow of Ho Chi Minh Society for Laser in Medicine and Surgery ;
*.Fellow of Vietnamese Society of Dermatology and Venereology;
*.International Fellow of American Academy of Dermatology